Tuesday, October 10, 2017

Primer on marijuana extracts

A primer on the various kinds of marijuana concentrate extraction methods and the resulting products. What it doesn't do is stress the importance of the strain and substrains used to make the extracts. A general strain rule for me: Sativa-dominant strains in the daytime, Indica-dominant strains before bed.

Click here for the Extract Primer

Monday, October 9, 2017

Interesting new technology for early detection of autoimmune diseases

This sounds interesting:

CYREX LABORATORIES INTRODUCES SALIVARY ASSESSMENT FOR EARLY AUTOIMMUNE DETECTION
Mucosal Immune Reactivity Screen is First to Encompass All Areas of The Cyrex System
PHOENIX (OCTOBER 10, 2017) – Cyrex Laboratories, a clinical laboratory specializing in functional immunology and autoimmune reactivity, continues to revolutionize the way healthcare professionals approach immune reactivity and intolerance. Today, Cyrex Laboratories unveils the Array 14 Mucosal Immune Reactivity Screen™, the first and only test capable of assessing mucosal immune reactivity in saliva as it measures SIgA and SIgM (Salivary Secretory Immunoglobulin A and M).
Early diagnosis of autoimmune reactivity is an essential step toward minimizing the severity and impact of a patient’s symptoms and condition. Mucosal production of IgA and IgM antibodies appears to be an early event in immune reactivity to dietary proteins, bacterial toxins and tissue antigens.

“Array 14 offers patients an excellent opportunity to identify an autoimmune response early,” said Jean Bellin, president of Cyrex Laboratories. “If an autoimmune issue is in the nascent phase of development, the dysfunction may not have reached the blood stream and standard blood tests would read as normal. There has never been such a comprehensive, early stage immune reactivity test like Array 14.” 
Array 14 is the first test to encompass all areas of The Cyrex System™, including:
  • markers of barrier integrity
  • immune reactions against all three environmental triggers associated with autoimmune reaction (food, chemical and pathogens)
  • autoimmune reactivity to self tissue
Array 14’s comprehensive range and ability to identify autoimmune reactivity early makes it an ideal test suited for annual wellness visits, and anyone who suspects a recent change in diet may be impacting their overall health. The complex and comprehensive Array 14 is also an excellent option for pediatricians, patients who have trouble with blood draws, or naturopathic doctors who prefer saliva screens to blood tests.

Patients with chronic inflammatory bowel conditions, a family history of autoimmune disease or who think they may be suffering from immune reactivity and intolerance are advised to inquire with their physician about ordering this innovative Array 14 from Cyrex Laboratories.

The Cyrex clinical consulting team is readily available for a consultation to discuss the results of patient testing upon request from a patient’s healthcare provider.

Physicians and other licensed healthcare professionals, as well as patients, can learn more about Array 14 and the other unique arrays that comprise The Cyrex System, at www.joincyrex.com.

Wednesday, August 9, 2017

Marijuana Field Research

In order to reduce pains (arthritis, MS) and stomach discomfort, I have been trying various strains and substrains of marijuana and, more recently, various product types: shatter, oils, tinctures, pills and other edibles (brownies from a Mary Jane mix). I think I'm honing in the strains and products to get me through the day.

I recently tried some 25 mg THC pills and found that they were great for reducing and even preventing pains... and giving a light buzz for about 6 hours. The effects start in about 1/2 hour after taking the pill, ramps up for another 15 minutes, then maintains its efficacy for another 5 or 6 hours. I think that the first ones I bought were Indica-based, which tends to make a person more drowsy. I want to try some Sativa-based pills in the future.

I also have an oil-based Sativa tincture. A few drops under the tongue and I feel better for a few hours. Its much more fast-acting than marijuana edibles (like the pills above) because it is absorbed quickly when taken sublingually. I think that this tincture also works to prevent pain, so is best taken before the pain or discomfort gets bad. Four drops gives about 12 mg of THC, which is about as much as you can hold under your tongue for a while until you have to swallow it. What you swallow isn't wasted: it just takes longer to affect you.

The brownies I find to be much too sweet, though if I stay up late enough and get the munchies, a half a brownie goes down very nice.

Of course, the fastest way to get marijuana-based relief is to vape or smoke dry weed or concentrates. For the day-time, a high THC Sativa weed or concentrate (like shatter) that doesn't make me too sleepy can be used as a quick pick-me-up on bad days. In the evening, just before bed, I vape my old standby: a 9/9 (%THC/%CBD) dry weed from Cannimed that usually helps me get to sleep quickly (along with sleeping pills). If I have a severe pain just before I go to bed, I take whiskey to calm it down. Sometimes I take whiskey even if I'm feeling no pain. 😁

It is now possible to get all these products from online dispensaries (usually based in BC) without a medical marijuana prescription... you just need to send them a digitized copy of government-issued ID. There are quite a few dispensaries that sell quality-controlled products and provide very clear information about what is in it. Contact me if you want to know more.

Wednesday, March 29, 2017

Changes

My last MRI showed more plaques and a shrinking hypothalamus. Not good news, but not surprising.

My mobility is quite obviously getting worse: mostly because of the weakness in my left leg and arm. Except for really short distances where I use my poles or a cane and someone's arm, I am only able to get around on my small scooter  (EV Rider Transport) which I use in the apartment and to the YMCA and in malls/restaurants, etc. I would recommend this to anyone that still has balance and enough strength to transfer yourself to chairs and so on.

My pain continues, especially in my left hip. Since my back surgery over two years ago, my sciatic pain continues to to be almost non-existent. Lower back pain, however, continues to get worse due to my osteoarthritis.

Pain is also the reason that my stomach is often upset. For pain I take neuro pain killer, Tylenol, marijuana and whiskey. Usually they work well enough to allow me to fall asleep. I would like to use less whiskey because it causes a poorer night's sleep... but that is still better than falling asleep at all.

My night spasms are almost gone: Baclofen and marijuana takes care of that. I rarely nap during the day any longer and seem to have more energy during the day. That may be because of the Modafinil I'm now taking.

I still do some exercises (when I'm not feeling lousy), either at physio, the pool, or at home.

But the real change for me is that my kids have both moved back into town from overseas AND I have a beautiful 9 month old granddaughter who has greatly increased the joy in my life. Pain or stomach upset, it doesn't matter... all I have to is think of her and my day feels so much better. I would recommend it to anyone!

Monday, December 19, 2016

Fampyra

I'm trying out the drug Fampyra, which is intended to help with walking. Apparently it helps about half the MSers that try it. I've been on it for three weeks. I did a walking test before I started the drug, then another one today. These are the results:

  • At my preferred walking speed, my pre-Fampyra times averaged 20.5 seconds, while my time after three weeks on the drug was 13.3 seconds.
  • At my fastest safe walking speed, my pre-Fampyra times averaged 16.5 seconds, while my time after three weeks on the drug was 10.8 seconds.
It appears that Fampyra is another drug I'll be on. There may have been some side-effects the first week (perhaps a little more fatigue and stomach upset), but those symptoms are so changeable that it's hard to tell if it was a reaction to the Fampyra.

As a side note, Fampyra may be helping a little with my ability to lift my lower leg using my hamstrings while on my stomach (or, perhaps, stopping my quads from kicking in while trying to use my hamstrings). At physio last week I had better results for that exercise than I'd had in a year.

Thursday, May 5, 2016

Six Years Later - Part 3

Coping
There are many ways and things I use to cope with my various problems:

  1. First and foremost among my coping "mechanisms" is my wonderful wife, Mary. Without her help and care, my life would be very different and my quality of life would be abysmal. Mary is my caregiver, my taxi-driver, my advisor and friend. Without her most of the rest of my coping mechanisms would be less useful or even impossible. 
  2. Exercise - I go to the physiotherapist twice a week for most of the year. I'm lucky to have a physiotherapist who is willing to work with me despite knowing that the best we can do is win small temporary victories. I work out in the pool three times a week, except when I'm away or am feeling my occasional sicknesses. One day a week I have a half hour, one-on-one Pilates instruction. A few days a week, I do some Pilates and physio at home, unless I'm not feeling well. Two or three times a week I use EMS (muscle stim) on my left leg and my left arm. I used to do yoga a few times a week, but after my back operation I stopped due to back pain and weakness. I'd like to start again, if I can find someone who can take the time to figure out what would work for me now without risking my back too much.
  3. Drugs - Lots of pills: for arthritis, nerve pain, leg spasms, cholesterol, and stomach upset (caused by some of the pills I take. I also take sleeping pills and my "happy" pills. For daytime discomfort and especially to help me sleep, I use marijuana. When the pain in my hip or back or when my stomach is real upset, I use whiskey: Wild Turkey bourbon is my favourite. 
  4. Mobility - While I can still get around with my poles or cane for short distances (maybe 100 meters max), for anything longer I use my scooters. I have my big scooter for longer distances and rougher terrain to go "scwalking" with Mary or "scjogging" with my daughter, Anna. I also have a small, foldable scooter for inside malls and buildings that Mary and I can lift in and out of the back of our car. I have also recently purchased a second (second-hand) big scooter to use at the cottage so we no longer have to trailer my other big scooter back and forth from home.
  5. Kindness - A big help to me is that my family and friends and strangers go way out of their way to make my life easier and to put up with my stumbling and shuffling. Nice people.
There are many other coping mechanisms I use, big and small, to make life easier for me, but those are the main ones. In my next post I'll talk about my future... and it's not all bad news!

Tuesday, May 3, 2016

Six Years Later - Part 2

The Bad News: 
  1. The weakness on my left side (arm and leg) has gotten much worse, meaning that I can't walk at all without a cane or poles, and even then only short distances. Stairs are becoming a real hassle, since it's getting really difficult to lift my left leg. Due to my poor walking and the icy conditions, Mary has taken to driving in front of the apartment building to pick me up, which means I haven't driven the car since last fall.
  2. My footdrop continues to get worse, to the point that when I'm tired or have had a few drinks I end up just dragging my left leg behind me.
  3. While I'm not as fatigued as before my liberation treatment (having to lay down, completely fagged out, four times a day at its worst) I am now having to have a nap after lunch... sometimes lasting a couple of hours or more. Strangely, if I have something particularly interesting to do, I don't feel the need for a nap.
  4. Ever since my spinal surgery a year and a half ago, the arthritis in my lower back has gotten much worse. This means that I regularily have lower back pain to the point that I feel nauseated. As well, the arthritic back, perhaps rubbing against my demylinated spots on my spinal chord, causes my left leg to spasm, sticking straight out for a few seconds after I get up out of a chair or out of bed or even resisting bending my left knee when I'm laying on my back and want to draw my leg in. It feels like my quads are turning on at the same time as my hamstrings. My physiotherapist has learned that stretching the quads reduces that reaction, at least for a few cycles of exercise.
  5. I seem to get stomach upsets fairly often, perhaps related to back pain and/or the very light flu-like symptoms I seem to feel every once in a while. When I get those symptoms (once every few weeks, lasting a few days), my eyes burn, my head feels stuffed up and my MS weakness gets worse.
  6. While my balance is still a bit better than before my treatment, it has gotten much worse in the last year or so. Of course, it's often hard to tell how much of that is due to lost balance and how much is because of a barely responsive back leg.
  7. I've had bad left hip pain and sciatic pain for many years (as my left leg and glue atrophied prior to and after my back surgery), but since the back surgery and my physiotherapy to bring back strength to my legs and glutes, most of the sciatic pain and some hip pain is gone. 
  8. My last MRI was not encouraging. I've got two new lesions on (in?) my brain, and my cerebellum is beginning to atrophy. At least now I have an excuse for my increasingly bad memory. 
That's the main part of my bad news. In my next part I'll talk about what I do to cope with these difficulties.

Sunday, May 1, 2016

Six Years Later - Part 1

I missed the actual anniversary by two days. On April 29th, 2010, I was "liberated". Soon after that I saw big improvements in several symptoms: in particular my autonomic functions,  my balance, my fatigue. Previous to the procedure, I was expecting to be in a wheelchair within a year. So where are things six years on? Well, there's good news and bad news. 

First the good news. My autonomic functions are still way better than they had been prior to my procedure. I haven't seen my urologist in years: he told me to only come back if things got worse again - and they haven't. My fatigue, while it's often enough a problem, is still way better than it was on April 28th, 2010. My balance is finally getting worse again, though probably still a little better than before the procedure. I'm still not in a wheelchair. 

The bad news? Well, there's quite a bit with respect to those things that the liberation procedure didn't help in the first place. However, I'll leave that for my Part 2 of this series of posts.

Tuesday, January 5, 2016

New Research on Vitamin D and MS

Happy New Year!

Scientists and health-care advocates are encouraged by new research that has found vitamin D may help repair damage to myelin — the protective sheath surrounding nerve fibers — in people with multiple sclerosis (MS).

The study, conducted by the University of Cambridge in England and published earlier this month in the Journal of Cell Biology, offers significant evidence that vitamin D could one day be used as a treatment for MS.

Researchers from the MS Society Cambridge Centre for Myelin Repair found that the vitamin D receptor protein pairs with an existing protein, called the RXR gamma receptor, which has already proven to help repair myelin.

The study, led by Professor Robin Franklin, determined that the production rate of myelin-making cells (oligodendrocytes) increased by 80% when added to brain stem cells where the proteins were present.

Further study is needed to determine whether the results found in the lab hold true in patients with MS during clinical trials. 

An estimated 100,000 Canadians have MS — the highest prevalence rate in the world. The Vitamin D Society, a Canadian non-profit group organized to increase awareness of the many health conditions strongly linked to vitamin D deficiency, is following the research closely. The organization encourages Canadians to be proactive in protecting their health and have their vitamin D levels tested annually.

In Canada, approximately 12 million Canadians do not meet vitamin D blood level requirements of 50 nmol/L set by Health Canada and the Institute of Medicine. This figure rises to 14 million — 40% of us — during winter months.

Saturday, July 18, 2015

A Day-Time-Pot Discovery

I've been trying several different strains of pot over the last couple of months, trying to find something that helps with pain and/or gives me a psychological lift during the day. I've found one that I think I'll stick with: Special Premium Electric Kush (http://store.medpotnow.com/super-premium-electric-kush.html). It isn't perfect, but ithe gives FAST, fairly LONG-LASTING pain relief and a bit of a high without too much dizziness or loss of balance. If you want some help with those symptoms, you might want to give it a try.